- Title
- Caspase inhibitors protect neurons by enabling selective necroptosis of inflamed microglia
- Creator
- Fricker, Michael; Vilalta, Anna; Tolkovsky, Aviva M.; Brown, Guy C.
- Relation
- Journal of Biological Chemistry Vol. 288, Issue 13, p. 9145-9152
- Publisher Link
- http://dx.doi.org/10.1074/jbc.M112.427880
- Publisher
- American Society for Biochemistry and Molecular Biology, Inc.
- Resource Type
- journal article
- Date
- 2013
- Description
- Background: Caspase-8 signaling can mediate apoptosis or survival depending on the cellular context. Results: Inflamed microglia survive because of caspase-dependent suppression of RIPK1-mediated necroptosis for survival. Conclusion: Caspase inhibition rescues neurons by triggering necroptosis of neurotoxic inflamed microglia. Significance: We demonstrate a novel neuroprotective mechanism of caspase inhibitors, namely killing of neurotoxicmicroglia by necroptosis.
- Subject
- caspase; necroptosis; microglia; neurodegenerative; neurons
- Identifier
- http://hdl.handle.net/1959.13/1295746
- Identifier
- uon:19108
- Identifier
- ISSN:0021-9258
- Language
- eng
- Full Text
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| Thumbnail | File | Description | Size | Format | |||
|---|---|---|---|---|---|---|---|
| View Details Download | ATTACHMENT01 | Publisher version (open access) | 2 MB | Adobe Acrobat PDF | View Details Download |